WebJul 17, 2012 · Platinum-based chemotherapy drugs are among the most powerful and widely used against cancer. However, they have toxic side effects, and tumors can become resistant to them. Cisplatin, the... WebOct 5, 2014 · Cisplatin and carboplatin are two of the most common types of platinum based treatments used in SCLC chemotherapy (Go and Adjei, 1999). In clinical trials, …
The resurgence of platinum-based cancer chemotherapy - Nature
WebMar 20, 2024 · Platinum-based anticancer drugs, including cisplatin, carboplatin, oxaliplatin, nedaplatin, and lobaplatin, are heavily applied in chemotherapy regimens. However, the intrinsic or acquired resistance severely limit the clinical application of platinum-based treatment. The underlying mechanisms are incredibly complicated. WebCisplatin, a class of platinum-containing anticancer drugs for the treatment of solid tumors, is a substrate of OCT2 and MATE1/MATE2-K. OCT2 is expressed in the basolateral membrane of proximal tubules and mediates the transport of cisplatin from the blood to proximal tubule cells. try to assist hostage rescue team
Comparing the efficacy and safety of cisplatin and other platinum-based …
WebFeb 7, 2024 · Platinum-based drugs cisplatin, carboplatin, and oxaliplatin are widely used for chemotherapeutic eradication of cancer. However, the side effects of platinum drugs, such as lack of selectivity, high systemic toxicity, and drug resistance, seriously limit their clinical application. With advancements in nanotechnology and chemical synthesis, Pt ... WebMar 2, 2024 · The risks of leukemia after platinum-based chemotherapy were 2.4, 3.8, and 5.6, respectively, less than 2 years, 2 to 4 years, and 5 or more years after the diagnosis of ovarian cancer (range, 1.3 ... WebFeb 7, 2024 · Platinum-based drugs cisplatin, carboplatin, and oxaliplatin are widely used for chemotherapeutic eradication of cancer. However, the side effects of platinum drugs, … try to attach process