Webb17 nov. 2024 · One intriguing possibility that warrants further study is whether Dyrk1a-CEP97 may fine tune Separase activity during centriole disengagement by regulating access of Plk1-Cdc20B-Spag5 to Separase or its regulatory proteins (e.g., securin) in the centriole–deuterosome complex rather than by directly controlling Plk1 localization to … WebbAmong them, PLK1 is studied mostly, 8 and plays important functions in regulating cell cycle. 9 According to previous studies, we concluded that high expression of PLK1 contributed to a poor prognosis in some human cancers. 10–12 Functionally, PLK1 promotes tumor progression through different pathways, for example, inhibition of PLK1 …
A WEE1 family business: regulation of mitosis, cancer …
Webb1 juni 2008 · Two fundamental questions in Plk1 regulation are which kinase phosphorylates and activates Plk1 and how the auto-inhibition by PBD is relieved at the G2/M transition. We report here that Aurora A is the physiological Plk1-activating kinase and that the G2-induced Bora protein interacts with Plk1 to control the accessibility of its … Webb22 apr. 2011 · Plk1 localizes to mitotic spindles and binds to both Nedd1 p-S460 and p-T550 epitopes generated by Cdc2. (A) Asynchronously growing HeLa cells either … koreatown mexico
PLK-1 Regulation of Asymmetric Cell Division in the Early
Webb2 maj 2024 · In vitro, BLM phosphorylation by CDK/PLK1/TOPBP1 stimulates the dissolution of topologically linked DNA intermediates by BLM-TOP3A. Thus, we propose that the CDK1-TOPBP1-PLK1 axis enhances BTR-mediated dissolution of recombination intermediates late in the cell cycle to suppress crossover recombination and curtail … WebbHuman polo-like kinases (PLK1-PLK4) have been implicated in mitotic regulation and carcinogenesis. PLK1 phosphorylates early mitotic inhibitor 1 (Emi1) to ensure mitosis … Webb29 sep. 2014 · DOI: 10.1083/jcb.201407087 Corpus ID: 17338456; Centriole maturation requires regulated Plk1 activity during two consecutive cell cycles @article{Kong2014CentrioleMR, title={Centriole maturation requires regulated Plk1 activity during two consecutive cell cycles}, author={Dong Kong and Veronica J. Farmer and Anil … manic fusion